Cragg G M, Newman D J, Weiss R B
Natural Products Branch, Frederick Cancer Research and Developmental Center, MD 21702-1201, USA.
Semin Oncol. 1997 Apr;24(2):156-63.
Nature has been a source of medicinal treatments for thousands of years, and plant-based systems continue to play an essential role in the primary health care of 80% of the world's population. Nature has provided many of the effective anticancer agents in current use, such as the microbially derived drugs, dactinomycin, bleomycin, and doxorubicin, and the plant-derived drugs vinblastine, irinotecan, topotecan, etoposide, and paclitaxel. The search for novel antitumor agents from natural sources continues with botanists, marine biologists, and microbiologists teaming up with chemists, pharmacologists, toxicologists, and clinicians in the investigation of coral reefs, rainforests, and deep subsurface thermal vents for novel bioactive compounds. The wealth of anticancer drugs of natural origin and critical aspects of the ongoing discovery and development process are discussed.
几千年来，大自然一直是药物治疗的来源，植物性医疗体系在全球80%人口的初级卫生保健中继续发挥着至关重要的作用。大自然提供了许多目前正在使用的有效抗癌药物，比如微生物衍生药物放线菌素、博来霉素和阿霉素，以及植物衍生药物长春碱、伊立替康、拓扑替康、依托泊苷和紫杉醇。植物学家、海洋生物学家和微生物学家正与化学家、药理学家、毒理学家和临床医生合作，在珊瑚礁、雨林和深海热液喷口中寻找新型生物活性化合物，从而继续从天然来源寻找新型抗肿瘤药物。本文将讨论丰富的天然抗癌药物以及正在进行的发现和开发过程中的关键方面。
