Pedersen K N, Haanaes H R
Acta Odontol Scand. 1979;37(4):181-7. doi: 10.3109/00016357909027580.
Porous Al2O3 ceramic material with pore size of 100-750 micrometers was used for implants placed subperiosteally as alveolar ridge augmentation onlays in six Cercopithecus monkeys. Clinical and radiographic examination during the postoperative period revealed rapid healing and anchorage of the implant in five of the animals. One implant was lost. The implants were retrieved after 4, 10, 11 and 12 months' implantation time. Histologic and microradiographic examination demonstrated fibrous and bone tissue invasion into the pore system at the base of the subperiosteal implant, with good anchorage of the ceramic material to the jaw. Only fibrous tissue was found to project into the ceramic openings on the implant sides facing the periosteum. Labeling of the mineralizing tissue was attempted using intravenously administered tetracycline (Reverin) and calcein (Calcein) at varying intervals prior to sacrifice, but the labeling results were not impressive.
孔径为100 - 750微米的多孔氧化铝陶瓷材料被用于六只猕猴的种植体，这些种植体作为牙槽嵴增高覆盖物置于骨膜下。术后的临床和影像学检查显示，五只动物的种植体愈合迅速且固定良好。有一个种植体丢失。在植入4、10、11和12个月后取出种植体。组织学和显微放射学检查表明，骨膜下种植体底部的孔隙系统有纤维组织和骨组织侵入，陶瓷材料与颌骨固定良好。仅在种植体面向骨膜一侧的陶瓷孔隙中有纤维组织伸入。在处死动物前的不同时间间隔，尝试通过静脉注射四环素（瑞弗林）和钙黄绿素（钙黄绿素）对矿化组织进行标记，但标记结果并不理想。
