Salama F, Sharawy M
Medical College of Georgia, Augusta.
J Oral Maxillofac Surg. 1989 Nov;47(11):1169-76. doi: 10.1016/0278-2391(89)90007-4.
The purpose of this study was to test the soft tissue and bone response to the implantation of porous polysulfone (PPSF) with and without demineralized bone powder (DBP) for ridge augmentation in Macaca fascicularis. The mandibular molar teeth were extracted in five adult female monkeys, followed by massive alveolectomy. Five to eight months later, PPSF + DBP was inserted subperiosteally on the left side, while PPSF alone was inserted on the right side. The animals were killed 42, 60, and 90 days following implantation. Specimens were processed for light microscopy, scanning electron microscopy, tetracycline labeling, and histomorphometric measurement of new bone. The 42-day specimens of the PPSF + DBP and PPSF revealed penetration of fibrous tissue rich in fibroblasts and blood vessels into the pores of the PPSF. At 60 and 90 days, the PPSF side showed organized fibrous tissue, but bone grew only for a short distance into the implant. In contrast, the PPSF + DBP side showed large amounts of bone formation, and bone almost covered the implant. The qualitative results were confirmed by histomorphometric examination.
本研究的目的是测试有脱矿骨粉（DBP）和无脱矿骨粉的多孔聚砜（PPSF）植入猕猴牙槽嵴增高时的软组织和骨反应。对5只成年雌性猕猴拔除下颌磨牙，随后进行大面积牙槽骨切除术。5至8个月后，将PPSF + DBP骨膜下植入左侧，单独将PPSF植入右侧。植入后42、60和90天处死动物。对标本进行光学显微镜检查、扫描电子显微镜检查、四环素标记以及新骨的组织形态计量学测量。PPSF + DBP和PPSF的42天标本显示富含成纤维细胞和血管的纤维组织长入PPSF的孔隙中。在60天和90天时，PPSF侧显示有组织化的纤维组织，但骨仅短距离长入植入物。相比之下，PPSF + DBP侧显示大量骨形成，且骨几乎覆盖了植入物。组织形态计量学检查证实了定性结果。
