Malaia L T, Abidov A A, Kniaz'kova I I
Ter Arkh. 1993;65(2):55-8.
A study is presented of hemodynamic effects and reactions of prostacyclin--thromboxane system in patients with stable (63 pts) and unstable angina pectoris (57 pts) who took aldizem 240 mg daily during 3 week. It was found that the aldizem improved clinical and hemodynamic indices and increased plasma concentration of 6-keto-PGF1 alpha and FPE2, but reduced TxB2 and PGF2 alpha. Also these changes depended on time of therapy: long-term therapy resulted in improvement of the prostacyclin-thromboxane balance.
一项针对63例稳定型心绞痛患者和57例不稳定型心绞痛患者的研究表明，这些患者连续3周每日服用240毫克地尔硫䓬，观察前列环素 - 血栓素系统的血流动力学效应和反应。结果发现，地尔硫䓬改善了临床和血流动力学指标，提高了血浆6 - 酮 - PGF1α和FPE2的浓度，但降低了TxB2和PGF2α的浓度。此外，这些变化取决于治疗时间：长期治疗可改善前列环素 - 血栓素平衡。
