Boufas D G, Koutras D A, Sideris D A, Koukoulommati-Spentza A, Moulopoulos S D
Endokrinologie. 1977;69(3):341-6.
Eleven men and 50 women with severe hypothyroidism were studied. All patients had a serum PBI less than 3.0 mug/100 ml, 131I 24 hours uptake less than 13% and a a photomotogram contraction and half relaxation time of 380 msec or more. Before exercise the mean +/- SE heart rate was 68.39 +/- 3.26/min, the PR interval 17.08 +/- 0.37 csec, the QRS voltage (sum of the QRS amplitude in leads I, II and III) 16.44 +/- 0.89 mm (10mm = 1.0 mV) and the T wave amplitude 0.06 +/- 0.15 mm. A significant correlation (p less than 0.05) existed between the PBI values and the QRS voltage. Following exercise there was a significant acceleration of the heart rate (+ 23.39/min, p less than 0.001), shortening of the PR interval (-0.66 csec, p less than 0.02) and T wave elevation (+ 0.40 mm, p less than 0.001). ST segment changes were not observed in any case. Replacement treatment in 7 cases resulted in a significant change in the resting heart rate (+ 11.86/min. p less than 0.025), PR interval (-3.28 mm, p less than 0.025) and T wave height (+ 2.50 mm, p less than 0.01). These findings suggest that exercise may be used in the differentiation between hypothyroidism and coronary heart disease. The theoretical importance of these findings is also discussed. An increase in cardiac energy demands during exercise may be the cause for some of the ECG changes observed on exertion.
对11名男性和50名重度甲状腺功能减退女性进行了研究。所有患者的血清蛋白结合碘（PBI）低于3.0微克/100毫升，24小时碘-131摄取率低于13%，光电容积描记图收缩和半舒张时间为380毫秒或更长。运动前，平均±标准误心率为68.39±3.26次/分钟，PR间期为17.08±0.37毫秒，QRS电压（I、II和III导联QRS波幅之和）为16.44±0.89毫米（10毫米 = 1.0毫伏），T波振幅为0.06±0.15毫米。PBI值与QRS电压之间存在显著相关性（p < 0.05）。运动后，心率显著加快（+23.39次/分钟，p < 0.001），PR间期缩短（-0.66毫秒，p < 0.02），T波升高（+0.40毫米，p < 0.001）。在任何情况下均未观察到ST段改变。7例患者进行替代治疗后，静息心率（+11.86次/分钟，p < 0.025）、PR间期（-3.28毫米，p < 0.025）和T波高度（+2.50毫米，p < 0.01）发生显著变化。这些发现表明，运动可用于鉴别甲状腺功能减退和冠心病。还讨论了这些发现的理论重要性。运动期间心脏能量需求的增加可能是运动时观察到的一些心电图变化的原因。
