Kauppi M, Pukkala E, Isomäki H
Rheumatism Foundation Hospital, Heinola, Finland.
Cancer Causes Control. 1997 Mar;8(2):201-4. doi: 10.1023/a:1018472213872.
The risk of hematologic malignancies was studied in Finnish patients with rheumatoid arthritis or Sjögren's syndrome, and the difference in the risk between those diseases was evaluated. The study cohorts comprised 676 patients with primary Sjögren's syndrome, 709 with secondary Sjögren's syndrome, and 9,469 with rheumatoid arthritis identified from the Finnish hospitals' national discharge register. The follow-up times were 5,336, 4,254 and 65,391 person-years, respectively. Data on the incidence of malignancies were collected from the files of the Finnish Cancer Registry. The incidence of hematologic malignancies was elevated in the study cohorts. The standardized incidence ratio (SIR) of non-Hodgkin's lymphoma was: 2.2 (95 percent confidence interval [CI] 1.5-3.1) for rheumatoid arthritis; 4.5 (CI = 1.5-11) for secondary Sjögren's syndrome; and 8.7 (CI = 4.3-16) for primary Sjögren's syndrome. The ratio of the SIR of primary Sjögren's syndrome cf rheumatoid arthritis alone was 3.9 (CI = 1.8-8.0) in non-Hodgkin's lymphoma, and 3.4 (CI = 1.2-8.1) in other hematologic cancers. The incidence of hematologic malignancies, especially that of non-Hodgkin's lymphoma, is elevated in patients with rheumatoid arthritis. It is higher in patients with secondary Sjögren's syndrome and highest in patients with primary Sjögren's syndrome. Differences in the immunologic aberration influence oncogenesis.
对芬兰类风湿关节炎或干燥综合征患者的血液系统恶性肿瘤风险进行了研究，并评估了这些疾病之间风险的差异。研究队列包括从芬兰医院国家出院登记处确定的676例原发性干燥综合征患者、709例继发性干燥综合征患者和9469例类风湿关节炎患者。随访时间分别为5336人年、4254人年和65391人年。恶性肿瘤发病率数据从芬兰癌症登记处的档案中收集。研究队列中血液系统恶性肿瘤的发病率有所升高。非霍奇金淋巴瘤的标准化发病率（SIR）为：类风湿关节炎患者为2.2（95%置信区间[CI]1.5 - 3.1）；继发性干燥综合征患者为4.5（CI = 1.5 - 11）；原发性干燥综合征患者为8.7（CI = 4.3 - 16）。原发性干燥综合征与单独类风湿关节炎的SIR比值在非霍奇金淋巴瘤中为3.9（CI = 1.8 - 8.0），在其他血液系统癌症中为3.4（CI = 1.2 - 8.1）。类风湿关节炎患者血液系统恶性肿瘤的发病率，尤其是非霍奇金淋巴瘤的发病率有所升高。继发性干燥综合征患者的发病率更高，原发性干燥综合征患者的发病率最高。免疫异常差异影响肿瘤发生。
