Tishler M, Caspi D, Almog Y, Segal R, Yaron M
Department of Rheumatology, Ichilov Hospital, Tel Aviv, Israel.
Ann Rheum Dis. 1992 May;51(5):604-6. doi: 10.1136/ard.51.5.604.
The incidence of lower urinary tract infection in 120 women with rheumatoid arthritis and secondary Sjögren's syndrome was evaluated retrospectively. Thirty one patients (26%) had secondary Sjögren's syndrome. Recurrent urinary tract infection was significantly more common in these patients (11/31) than in patients without Sjögren's syndrome (4/89). Habitual leucocyturia was also more common in patients with secondary Sjögren's syndrome (18/31) than in patients with rheumatoid arthritis without Sjögren's syndrome (8/89). Of seven patients with vaginal sicca symptoms, six had recurrent urinary tract infection. Urinary 24 hour mucopolysaccharide excretion in 20 patients with Sjögren's syndrome was similar to the excretion in 10 patients without Sjögren's syndrome. These results show that recurrent urinary tract infection is significantly more common in women with rheumatoid arthritis and secondary Sjögren's syndrome. A local deficit in protective urinary mucosal secretion or other immune mechanisms may be responsible for this susceptibility.
对120例类风湿关节炎继发干燥综合征的女性患者下尿路感染的发生率进行了回顾性评估。31例患者（26%）患有继发干燥综合征。这些患者（11/31）复发性尿路感染的发生率显著高于无干燥综合征的患者（4/89）。继发干燥综合征患者（18/31）习惯性白细胞尿的发生率也高于无干燥综合征的类风湿关节炎患者（8/89）。在7例有阴道干燥症状的患者中，6例有复发性尿路感染。20例干燥综合征患者的24小时尿黏多糖排泄量与10例无干燥综合征患者的排泄量相似。这些结果表明，类风湿关节炎继发干燥综合征的女性复发性尿路感染明显更常见。保护性尿黏膜分泌或其他免疫机制的局部缺陷可能是导致这种易感性的原因。
