Wenneberg S R, Schneider R H, Walton K G, Maclean C R, Levitsky D K, Salerno J W, Wallace R K, Mandarino J V, Rainforth M V, Waziri R
Department of Physiological and Biological Sciences, Maharishi University of Management, Fairfield, IA 52557, USA.
Int J Neurosci. 1997 Jan;89(1-2):15-28. doi: 10.3109/00207459708988461.
Cardiovascular responses to stress reactivity has been proposed as a risk factor for hypertension. In this study, we evaluated the effects of stress reduction on both laboratory cardiovascular reactivity and ambulatory blood pressure in real life on 39 normotensive male subjects who were pretested for ambulatory blood pressure and cardiovascular reactivity to stress using a battery of laboratory stressors. Thereafter, subjects were randomly assigned to practice either the Transcendental Meditation (TM) technique or a cognitive-based stress education control (SEC) for four months. After 4 months, there was no change in cardiovascular response to stressors between the TM and control groups. However, the subjects regularly practicing TM demonstrated a significant reduction of 9 mm Hg (p < .04) in average ambulatory DBP compared to controls. Since ambulatory BP monitoring has been shown to be a better predictor of cardiovascular complications of hypertension than clinic BP, this finding may have important implications for primary prevention of CVD in normotensive subjects.
心血管对应激反应性的反应已被提出作为高血压的一个风险因素。在本研究中，我们评估了减压对39名血压正常男性受试者的实验室心血管反应性和现实生活中的动态血压的影响，这些受试者在使用一系列实验室应激源对动态血压和心血管对应激的反应性进行预测试后，被随机分配到超觉静坐（TM）技术组或基于认知的应激教育对照组（SEC），练习四个月。4个月后，TM组和对照组之间对应激源的心血管反应没有变化。然而，与对照组相比，定期练习TM的受试者平均动态舒张压显著降低了9毫米汞柱（p < 0.04）。由于动态血压监测已被证明比诊所血压更能预测高血压的心血管并发症，这一发现可能对血压正常受试者的心血管疾病一级预防具有重要意义。
