对导致“油症”的受污染米糠油中多氯二苯并二恶英/多氯二苯并呋喃及共平面多氯联苯毒性的重新评估。

Reassessment of PCDD/DFs and Co-PCBs toxicity in contaminated rice-bran oil responsible for the disease "Yu-Cheng".

作者信息

Soong D K, Ling Y C

机构信息

Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan, R.O.C.

出版信息

Chemosphere. 1997 Mar-Apr;34(5-7):1579-86. doi: 10.1016/s0045-6535(97)00453-0.

DOI:10.1016/s0045-6535(97)00453-0

PMID:9134689

Abstract

Reassessment of dibenzo-p-dioxins and dibenzofurans (PCDD/DFs) and coplanar polychlorinated biphenyls (Co-PCBs) in toxic Yu-Cheng rice-bran oil was carried out. The contaminating source appears to be a mixture of KC-400 and KC-500. The oil contains 176 micrograms/g PCBs and 37.194 ng/g 2,3,7,8,-TCDD toxicity equivalency (TEQ). The TEQ contributions from the PCDDs (4.472 ng/g), PCDFs (19.568 ng/g), and Co-PCBs (13.154 ng/g) are 12% 53% and 35%, respectively. Complete identification and quantitation suggests that 2,3,4,7,8-PeCDF, 1,2,3,4,7,8-HxCDF, 2,3,7,8,-TCDF. 2,3,7,8-TCDD, 1,2,3,7,8-PeCDD and PCB# 77 are candidates for the primary causal agents of Yu-Cheng disease.

摘要

对有毒的“油症”米糠油中的二苯并对二恶英和二苯并呋喃（PCDD/DFs）以及共平面多氯联苯（Co-PCBs）进行了重新评估。污染源似乎是KC-400和KC-500的混合物。该油含有176微克/克的多氯联苯和37.194纳克/克的2,3,7,8-四氯二苯并对二恶英毒性当量（TEQ）。多氯二苯并对二恶英（4.472纳克/克）、多氯二苯并呋喃（19.568纳克/克）和共平面多氯联苯（13.154纳克/克）对TEQ的贡献分别为12%、53%和35%。完整的鉴定和定量表明，2,3,4,7,8-五氯二苯并呋喃、1,2,3,4,7,8-六氯二苯并呋喃、2,3,7,8-四氯二苯并呋喃、2,3,7,8-四氯二苯并对二恶英、1,2,3,7,8-五氯二苯并对二恶英和多氯联苯#77是“油症”疾病的主要致病因素。