Iida T, Hirakawa H, Matsueda T, Nakagawa R
Fukuoka Institute of Health and Environmental Sciences, Japan.
Fukuoka Igaku Zasshi. 1997 May;88(5):169-76.
Concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), coplanar polychlorinated biphenyls (Co-PCBs) and total polychlorinated biphenyls (PCBs) were analyzed in blood samples from 83 Yusho patients and 39 normal control subjects in 1995. The average concentrations of PCDDs, PCDFs and Co-PCBs in the blood of Yusho patients were 14, 128 and 14 pg toxic equivalent quantity (TEQ)/g, lipid, respectively. The levels of these compounds in the blood of normal subjects were 14, 10 and 8 pg/g lipid, respectively. Thus, although the average levels of PCDDs and Co-PCBs in the blood of Yusho patients were similar to those of control subjects, the PCDF level in Yusho patients was 12.8 fold higher than in normals. Average concentrations of total PCBs in the blood of Yusho patients and normal control subjects were 789 and 339 ng/g lipid, respectively. Thus, the PCB level in the blood of Yusho patients was 2.3 fold higher than in normal subjects. To test the reproducibility of determination of PCDDs, PCDFs and Co-PCBs, three normal blood samples were analyzed twice. These analyses gave similar results each time. Since, these compounds could be measured in five-milliliter blood samples, they can be monitored in Yusho patients.
1995年，对83名油症患者和39名正常对照者的血液样本进行了多氯代二苯并 - 对二噁英（PCDDs）、多氯代二苯并呋喃（PCDFs）、共平面多氯联苯（Co - PCBs）和总多氯联苯（PCBs）浓度的分析。油症患者血液中PCDDs、PCDFs和Co - PCBs的平均浓度分别为14、128和14皮克毒性当量（TEQ）/克脂质。正常受试者血液中这些化合物的水平分别为14、10和8皮克/克脂质。因此，虽然油症患者血液中PCDDs和Co - PCBs的平均水平与对照者相似，但油症患者的PCDF水平比正常人高12.8倍。油症患者和正常对照者血液中总PCBs的平均浓度分别为789和339纳克/克脂质。因此，油症患者血液中的PCB水平比正常受试者高2.3倍。为测试PCDDs、PCDFs和Co - PCBs测定的重现性，对三个正常血液样本进行了两次分析。每次分析结果相似。由于这些化合物可以在5毫升血液样本中进行测量，因此可以对油症患者进行监测。
