Jay P, Bergé-Lefranc J L, Marsollier C, Méjean C, Taviaux S, Berta P
Centre de Recherche de Biochimie Macromolécularie, CNRS ERS 155-INSERMU249, Montpellier, France.
Oncogene. 1997 Apr 10;14(14):1753-7. doi: 10.1038/sj.onc.1200986.
Complementary DNA encoding the human CYR61 protein was isolated from human embryonic tissues and mapped to chromosome 1p22-p31. We show that CYR61 encodes a 381 amino acid protein rich in cysteine and proline residues that is strongly conserved with the mouse homologue. Sequence analysis reveals the presence of several distinct protein domains which confer a mosaic structure to this protein and makes human CYR61 a member of a recently described growth regulator family that includes several proto-oncogene products. From our results we hypothesize that this new immediate early gene may play a role in cell commitment during embryogenesis and more generally in the control of cell proliferation.
编码人CYR61蛋白的互补DNA从人胚胎组织中分离出来，并定位到1号染色体的1p22 - p31区域。我们发现CYR61编码一种富含半胱氨酸和脯氨酸残基的381个氨基酸的蛋白质，它与小鼠同源物高度保守。序列分析揭示了几个不同的蛋白质结构域的存在，这些结构域赋予该蛋白质一种镶嵌结构，使人CYR61成为最近描述的生长调节因子家族的一员，该家族包括几种原癌基因产物。根据我们的结果，我们推测这个新的立即早期基因可能在胚胎发育过程中的细胞定向中发挥作用，更广泛地说，在细胞增殖的控制中发挥作用。
