Gouyon J B, Geneste B, Semama D S, Françoise M, Germain J F
Service de Pédiatrie 2, Hôpital d'Enfants, Dijon, France.
Arch Dis Child Fetal Neonatal Ed. 1997 Mar;76(2):F126-7. doi: 10.1136/fn.76.2.f126.
Eight preterm infants were given intravenous nicardipine, a calcium channel blocker, to treat systemic hypertension (renal artery thrombosis (n = 3); dexamethasone for management of bronchopulmonary dysplasia (n = 2); unexplained (n = 3). Nicardipine doses ranged from 0.5 to 2.0 micrograms/kg/min and were given for three to 36 days (mean (SD) 15.9 (10.3) days). Systolic blood pressure had significantly decreased after 12 and 24 hours of nicardipine treatment (-17 (17)% and -21 (10)%, respectively). Diastolic blood pressure significantly decreased after 24 hours of treatment (-22 +/- 16%). The decrease in blood pressure remained significant over the subsequent days of treatment. No hypotension or other clinical side effects were observed. It is concluded that intravenous nicardipine could be a first line treatment for hypertension in preterm infants.
八名早产儿接受了静脉注射尼卡地平（一种钙通道阻滞剂）以治疗系统性高血压（肾动脉血栓形成（n = 3）；使用地塞米松治疗支气管肺发育不良（n = 2）；原因不明（n = 3））。尼卡地平剂量范围为0.5至2.0微克/千克/分钟，给药时间为3至36天（平均（标准差）15.9（10.3）天）。尼卡地平治疗12小时和24小时后，收缩压显著下降（分别下降-17（17）%和-21（10）%）。治疗24小时后舒张压显著下降（-22±16%）。在随后的治疗天数中，血压下降仍很显著。未观察到低血压或其他临床副作用。结论是静脉注射尼卡地平可能是早产儿高血压的一线治疗方法。
