Levene M I, Gibson N A, Fenton A C, Papathoma E, Barnett D
Department of Child Health, Leicester University School of Medicine.
Dev Med Child Neurol. 1990 Jul;32(7):567-74. doi: 10.1111/j.1469-8749.1990.tb08540.x.
A continuous infusion of nicardipine was given to four severely asphyxiated fullterm infants who were at high risk for adverse outcome and had abnormal cerebral Doppler haemodynamic studies. The heart rate increased in all four infants and mean arterial blood pressure (MAP) fell in three. Two infants had a sudden and marked fall in MAP, together with severe impairment of skin blood-flow and a concurrent fall in cerebral blood-flow velocity. The serum level of nicardipine was less than 40ng/mL in all cases. The use of nicardipine, and possibly other calcium-channel blockers, may be associated with marked hypotension, and if there is no cerebral autoregulation, may cause further cerebral hypoperfusion, so use of these drugs in asphyxiated newborn infants should only be attempted if blood pressure is carefully monitored.
对四名严重窒息的足月儿持续输注尼卡地平，这些婴儿预后不良风险高且脑多普勒血流动力学研究异常。所有四名婴儿心率均增加，三名婴儿平均动脉血压（MAP）下降。两名婴儿MAP突然显著下降，同时皮肤血流严重受损，脑血流速度也随之下降。所有病例中尼卡地平血清水平均低于40ng/mL。使用尼卡地平以及其他可能的钙通道阻滞剂可能会导致显著低血压，并且如果没有脑自动调节功能，可能会导致进一步的脑灌注不足，因此只有在仔细监测血压的情况下才应尝试在窒息新生儿中使用这些药物。
