Buadu L D, Murakami J, Murayama S, Hashiguchi N, Sakai S, Toyoshima S, Masuda K, Kuroki S, Ohno S
Department of Radiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Comput Assist Tomogr. 1997 May-Jun;21(3):421-30. doi: 10.1097/00004728-199705000-00016.
Our goal was to review patterns of peripheral enhancement on contrast-enhanced MRI of the breast and to correlate radiologic findings with pathologic features.
We reviewed the MR images of 124 consecutive women with breast lesions. Peripheral enhancement was identified in 35 (32 malignant, 3 benign) lesions. MRI findings were correlated with pathologic features including microvessel density and distribution determined histologically.
Early peripheral enhancement with centripetal progression was seen in invasive carcinomas with a high peripheral and a low central microvessel density, associated with fibrosis and/or necrosis (n = 18; 15 with central fibrosis, 2 with fibrosis and necrosis, and 1 with necrosis alone). Early peripheral enhancement with minimal or no change in enhancement was seen in both malignant (n = 10) and benign (n = 3) lesions. Delayed peripheral enhancement with centrifugal progression was seen in carcinomas that had an expansive growth pattern and a high marginal vessel density with or without a vascularized rim of connective tissue (n = 4).
Early peripheral enhancement with centripetal progression appears to be fairly specific for carcinomas, whereas early enhancement with minimal or no centripetal progression, although more common in malignant tumors, may be seen in some benign lesions as well.
我们的目标是回顾乳腺对比增强磁共振成像（MRI）的外周强化模式，并将放射学表现与病理特征相关联。
我们回顾了124例连续患有乳腺病变女性的MR图像。在35个病变（32个恶性，3个良性）中发现了外周强化。MRI表现与病理特征相关，包括通过组织学确定的微血管密度和分布。
在具有高外周和低中心微血管密度、伴有纤维化和/或坏死的浸润性癌中可见早期外周强化并向心性进展（n = 18；15例伴有中心纤维化，2例伴有纤维化和坏死，1例仅伴有坏死）。在恶性病变（n = 10）和良性病变（n = 3）中均可见早期外周强化且强化变化最小或无变化。在具有膨胀性生长模式且边缘血管密度高、伴有或不伴有血管化结缔组织边缘的癌中可见延迟外周强化并离心性进展（n = 4）。
早期外周强化并向心性进展似乎对癌具有相当的特异性，而早期强化且向心性进展最小或无进展，虽然在恶性肿瘤中更常见，但在一些良性病变中也可能出现。
