El Gammal C, Pagnoni A, Kligman A M, el Gammal S
Foundation for Basic Cutaneous Research, Philadelphia, Pennsylvania, USA.
Clin Exp Dermatol. 1996 Sep;21(5):338-43.
Clinical grading of dry skin syndromes (xerosis) is beset by many variables which limit its reliability. Removing scales onto adhesive coated discs (D-Squames) has provided a means for objective measurement of xerotic states. Using image analysis we have modified the basic procedure to assure greater accuracy and reproducibility. The distribution of grey values on the discs was determined, from which a single value of the degree of scaling was calculated. We term this the scaling index. To induce xerosis, the lower legs of 22 women, aged 26-64, were washed daily for 10 days with soap. After washing, one side received a moisturizing lotion, the other served as an untreated control. At specified intervals, scaling was graded clinically, electrical conductance was measured and D-Squames were obtained. On the moisturizer-treated legs there was a significant decrease in dryness grades and scaling indices at all time points. Conductance was significantly increased on days 8 and 11. The untreated washed legs showed no changes in clinical grades, although conductance significantly decreased and the scaling indices increased in the last stage of the study. D-Squame analysis unequivocally revealed the beneficial effect of a moisturizer on soap-induced xerosis and the expected increase in scaliness without treatment.
干性皮肤综合征（皮肤干燥症）的临床分级受到许多变量的困扰，这限制了其可靠性。将鳞屑粘在涂有粘合剂的圆盘（D-Squames）上，为客观测量皮肤干燥状态提供了一种方法。我们使用图像分析对基本程序进行了改进，以确保更高的准确性和可重复性。确定圆盘上灰度值的分布，据此计算出鳞屑程度的单一值。我们将其称为鳞屑指数。为诱发皮肤干燥症，对22名年龄在26至64岁之间的女性的小腿，每天用肥皂清洗，持续10天。清洗后，一侧涂抹保湿乳液，另一侧作为未处理的对照。在特定时间间隔，对鳞屑进行临床分级，测量电导率并获取D-Squames。在涂抹保湿乳液的小腿上，所有时间点的干燥等级和鳞屑指数均显著下降。在第8天和第11天，电导率显著增加。未处理的清洗小腿临床分级无变化，尽管在研究的最后阶段电导率显著下降且鳞屑指数增加。D-Squame分析明确揭示了保湿剂对肥皂诱发的皮肤干燥症的有益作用，以及未经治疗时鳞屑增加的预期情况。
