Thatte U M, Rao S G, Dahanukar S A
Dept of Pharmacology, Seth GS Medical College, Parel, Bombay, Maharashtra.
J Postgrad Med. 1994 Oct-Dec;40(4):202-3.
Tinospora cordifolia (Tc) is an Indian medicinal plant with proven immunomodulatory activity. This study was performed to elucidate its possible mechanism of action. We measured CFU-GM Cotony forming units of the granulocyte-macrophage series in serum of mice treated with Tc. We found that 10 days treatment with Tc (100 mg/ kg/d) induced a significant (p < 0.01) increase in the number of CFU-GM (255 +/- 49.32 vs 38.51 +/- 9.98) This suggests that activation of macrophages by Tc leads to increase in GM-CSF which leads to leucocytosis and improved neutrophil function.
匙羹藤是一种具有经证实的免疫调节活性的印度药用植物。进行本研究以阐明其可能的作用机制。我们测量了用匙羹藤处理的小鼠血清中粒细胞-巨噬细胞系列的集落形成单位（CFU-GM）。我们发现，用匙羹藤（100毫克/千克/天）处理10天可使CFU-GM数量显著增加（p < 0.01）（255 +/- 49.32对38.51 +/- 9.98）。这表明匙羹藤对巨噬细胞的激活导致GM-CSF增加，进而导致白细胞增多和中性粒细胞功能改善。
