Berkanovic E, Oster P, Wong W K, Bulpitt K, Clements P, Sterz M, Paulus H
School of Public Health, University of California at Los Angeles 90095, USA.
Arthritis Care Res. 1996 Dec;9(6):257-62.
To examine the role of socioeconomic status (SES) in physical functioning, pain, and depressive symptoms among newly diagnosed rheumatoid arthritis (RA) patients with severe disease.
Data are from 118 non-Hispanic patients of European origin at baseline of a longitudinal study of early, severe RA. Outcome measures with the Health Assessment Questionnaire (HAQ) functional disability index, the HAQ visual analog pain scale, and the Center for Epidemiologic Studies Depression Scale. Hierarchical regression analyses were conducted using a health status block (disease activity and comorbidities), a non-SES related social structure block (age, sex and Lubben Social Network Scale), and indicators of SES (income and education).
Non-SES related social structure and SES were important independent determinants of functional disability and depressive symptoms, but both they and the health status variables were unrelated to pain. Further, neither income nor education was related to disease activity or comorbidities.
It cannot be argued from these data that poorer health status explains the link between SES and disability and depressive symptoms. Although, at baseline, the psychosocial effects of early RA are more severe for those with SES, the disease does not appear to be more severe. It may be that the biologic impact of status differentials will become clearer as the effects of treatment and the course of the disease unfold over time.
探讨社会经济地位(SES)在新诊断的重症类风湿关节炎(RA)患者身体功能、疼痛及抑郁症状方面所起的作用。
数据来自一项针对早期重症RA的纵向研究基线期的118名非西班牙裔欧洲裔患者。采用健康评估问卷(HAQ)功能残疾指数、HAQ视觉模拟疼痛量表以及流行病学研究中心抑郁量表作为结局指标。使用健康状况模块(疾病活动度和合并症)、非SES相关的社会结构模块(年龄、性别和鲁本社会网络量表)以及SES指标(收入和教育程度)进行分层回归分析。
非SES相关的社会结构和SES是功能残疾及抑郁症状的重要独立决定因素,但它们与健康状况变量均与疼痛无关。此外,收入和教育程度均与疾病活动度或合并症无关。
从这些数据无法推断出较差的健康状况可解释SES与残疾及抑郁症状之间的关联。虽然在基线期,早期RA对SES较低者的心理社会影响更为严重,但疾病本身似乎并不更严重。随着治疗效果和疾病进程随时间展开,社会地位差异的生物学影响可能会变得更加明显。