[Fibrinolysis in several organs following splenectomy in animals].

Spleenectomy was found to have a disturbing effect on the anticoagulating system (ACS) function and to elicit changes of the fibrinolytic activity in tissues of some organs. At the greatest ACS suppression, on the 7th day after spleenectomy, the animals had a decreased total fibrinolytic activity (TFA) in extracts from the liver and lungs, while the activity was utterly absent in extracts from the heart. By the end of the restoration period of ACS function, on the 21st day after the surgery, in experimental animals no fibrinolysis was revealed in the extract from the myocardium, neither the unfermentative fibrinolysis (UF) was observed in extracts from the liver and lungs. Simultaneously a considerable fibrinolytic activity occurred in the tissues of kidneys and thymus, mainly on account of UF. Evidently, after spleenectomy the biosynthesis and accumulation of agents exerting unfermentative fibrinolytic activity is transferred from some organs to others.