Liutova L V, Andreenko G V, Karabasova M A, Rybakina E G, Kozinets I A, Ashmarin I P
Vopr Med Khim. 1989 Jul-Aug;35(4):75-8.
Distinct decrease in fibrinolytic activity of both whole blood plasma and its euglobulin fraction, occurring due to liberation of an inhibitor of plasminogen activator into circulation, was observed within 2-4 hrs after a single intravenous administration of rabbit interleukin-I into rats at a dose of 50 micrograms/kg, while the activator activity was increased in kidney heart, spleen and lung tissues. The similar data were obtained if the dose was either increased up to 150 micrograms/kg or decreased down to 5 micrograms/kg and 0.5 micrograms/kg, but the effect observed proved to be dose-dependent. Three injections of interleukin-I caused more pronounced increase in concentration of fibrinogen and antiplasmins as compared with controls.
给大鼠单次静脉注射剂量为50微克/千克的兔白细胞介素-I后，在2至4小时内观察到全血血浆及其优球蛋白部分的纤溶活性明显降低，这是由于纤溶酶原激活物抑制剂释放入循环所致，而在肾脏、心脏、脾脏和肺组织中激活物活性增加。如果剂量增加至150微克/千克或降低至5微克/千克和0.5微克/千克，也会获得类似数据，但观察到的效应证明是剂量依赖性的。与对照组相比，三次注射白细胞介素-I导致纤维蛋白原和抗纤溶酶浓度更明显升高。
