Oka H, Mochio S, Sato H, Katayama K
Internal Medicine (III), Jikei University School of Medicine, Tokyo, Japan.
Eur Neurol. 1997;37(3):186-9. doi: 10.1159/000117432.
QTc intervals were measured in 30 patients with Parkinson's disease and 30 healthy control subjects. The mean value of QTc intervals in patients with Parkinson's disease significantly exceeded that of healthy controls (418 +/- 14 ms vs. 403 +/- 18 ms). Prolongation of the QTc interval was unrelated to the administration of levodopa. The mean QTc interval in patients whose Hoehn and Yahr score was III or more was significantly greater than that of patients whose score was II or less (424 +/- 12 ms vs. 410 +/- 12 ms). A significant correlation between the QTc interval and the Valsalva ratio, as well as the overshoot, was identified. The QTc interval is closely related to autonomic nervous system dysfunction, including abnormal baroreceptor reflex function, in patients with Parkinson's disease.
对30例帕金森病患者和30名健康对照者测量了QTc间期。帕金森病患者的QTc间期平均值显著超过健康对照者（418±14毫秒对403±18毫秒）。QTc间期延长与左旋多巴的使用无关。Hoehn和Yahr评分III级或更高的患者的平均QTc间期显著大于评分II级或更低的患者（424±12毫秒对410±12毫秒）。确定QTc间期与瓦尔萨尔瓦比率以及过冲之间存在显著相关性。在帕金森病患者中，QTc间期与自主神经系统功能障碍密切相关，包括压力感受器反射功能异常。
