葡萄球菌属和肠球菌属对替考拉宁和万古霉素的敏感性研究

[Study of the susceptibility of Staphylococcus sp. and Enterococcus sp. to teicoplanin and vancomycin].

作者信息

Mimica I, Mendes C M, Mimica L, Oplustil C, Pignatari A C, Sader H

机构信息

Faculdade de Ciências Médicas da Santa Casa de São Paulo.

出版信息

Rev Assoc Med Bras (1992). 1996 Jul-Sep;42(3):147-50.

PMID:9138356

Abstract

PURPOSE

The study was performed in order to evaluate the susceptibility of Enterococcus and Staphylococcus to teicoplanin and vancomycin.

METHODS

150 Enterococcus strains and 450 Staphylococcus strains (298 Staphylococcus aureus and 152 negative coagulase strains) isolated in three Brazilian hospitals were studied. The MICs were determined using teicoplanin and vancomycin E Test strips. The range of the antimicrobial concentration in each strip went from 256 mcg/mL to 0.016 mcg/mL. Diffusion tests using disks impregnated with 10 mcg of teicoplanin and 30 mcg of vancomycin were also performed.

RESULTS

All the 298 Staphylococcus aureus strains were susceptible to the two antimicrobials. Three of the 152 negative coagulase strains presented intermediate susceptibility to teicoplanin (MICs between 8 and 16 mcg/mL). Four of the 150 Enterococcus strains presented intermediate susceptibility to vancomycin but were totally susceptible to teicoplanin.

CONCLUSION

According to these results teicoplanin and vancomycin are good therapeutical options in the treatment of staphylococcal and enterococcal infections.

摘要

目的

进行本研究以评估肠球菌和葡萄球菌对替考拉宁和万古霉素的敏感性。

方法

对巴西三家医院分离出的150株肠球菌菌株和450株葡萄球菌菌株（298株金黄色葡萄球菌和152株凝固酶阴性菌株）进行研究。使用替考拉宁和万古霉素E测试条测定最低抑菌浓度（MIC）。每条测试条上抗菌药物浓度范围为256微克/毫升至0.016微克/毫升。还进行了使用含10微克替考拉宁和30微克万古霉素的纸片扩散试验。