Israel A, Cierco M, Salazar M, Barbella Y
Department of Biological Sciences, Universidad Central de Venezuela, Caracas, Venezuela.
Brain Res Bull. 1996;39(6):401-5. doi: 10.1016/0361-9230(96)00032-9.
Intracerebroventricular (IVT) administration of renin (R) to conscious male hydrated rats induces an increase in sodium excretion. The involvement of brain dopaminergic neurons in the renal action of IVT-R was investigated. Renin-induced natriuretic action was prevented by domperidone and by inhibition of tyrosine hydroxylase activity with alpha-methyl-p-tyrosine treatment. In addition, this effect was absent following selective central dopaminergic denervation with 6-hydroxydopamine (IVT) in combination with desmethylimipramine (IP). Our results suggest that renin acts centrally, at least in part, via an interaction with endogenous dopamine systems.
向清醒的雄性水合大鼠脑室内（IVT）注射肾素（R）会导致钠排泄增加。研究了脑多巴胺能神经元在IVT-R肾脏作用中的参与情况。多潘立酮以及用α-甲基-对-酪氨酸处理抑制酪氨酸羟化酶活性可阻止肾素诱导的利钠作用。此外，在用6-羟基多巴胺（IVT）联合去甲丙咪嗪（腹腔注射）进行选择性中枢多巴胺能去神经支配后，这种作用消失。我们的结果表明，肾素至少部分地通过与内源性多巴胺系统相互作用在中枢发挥作用。
