Rosenbloom A L, Lezotte D C, Weber F T, Gudat J, Heller D R, Weber M L, Klein S, Kennedy B B
Diabetes. 1977 Nov;26(11):1052-5. doi: 10.2337/diab.26.11.1052.
Photon absorption measurements of forearm bone density in 196 insulin-dependent patients, age 6--26 years, were compared with findings in 124 controls. Expected density, gm. Ca/cm.2 bone width (M/W), was calculated from regressions of M/W on ulnar length for white and black male and female controls. There were no significant correlations between M/W differences from expected and serum Ca, Mg, P, or alkaline phosphatase levels, estimated physical activity level, insulin dosage, or the presence of joint contracture. White females averaged 8.2 per cent (+/- 1 S.E.M.) loss of M/W, as against white male average loss of 4.7 per cent +/- 1 and black female loss of 2 per cent +/- 2 (p less than 0.001); the black male population was too small for separate analysis. M/W loss greater than 10 per cent was seen in 29 per cent of white males, 19 per cent of blacks, and 48 per cent of white females (p less than 0.02). When the groups were further divided into those with duration of diabetes less than or equal to five years and those with duration greater than five years, significant reduction in M/W average loss over time was seen with white females (10.6 per cent +/- 1.2 to 3.7 per cent+/- 1.5, p less than 0.0001). Expression of this defect in bone mineralization is controlled by race and sex acting independently of each other.
对196名年龄在6至26岁的胰岛素依赖型患者的前臂骨密度进行了光子吸收测量，并与124名对照者的测量结果进行了比较。根据白人及黑人男性和女性对照者的尺骨长度与骨宽度/体重（M/W）的回归关系，计算出预期骨密度（克钙/平方厘米骨宽度）。骨宽度/体重与预期值的差异与血清钙、镁、磷或碱性磷酸酶水平、估计的体力活动水平、胰岛素剂量或关节挛缩的存在之间均无显著相关性。白人女性的骨宽度/体重平均损失8.2%（±1标准误），白人男性平均损失4.7%±1，黑人女性损失2%±2（p<0.001）；黑人男性样本量太小，无法单独分析。29%的白人男性、19%的黑人及48%的白人女性的骨宽度/体重损失超过10%（p<0.02）。当将这些组进一步分为糖尿病病程小于或等于5年和病程大于5年的两组时，发现白人女性随着时间推移骨宽度/体重平均损失显著降低（从10.6%±1.2降至3.7%±1.5，p<0.0001）。这种骨矿化缺陷的表现受种族和性别的独立影响。
