Han P, Turpie A G, Genton E
Blood. 1979 Nov;54(5):1192-6.
To elucidate the usefulness of beta-thromboglobulin (beta TG) in the differentiation of the mechanism of thrombocytopenia, plasma beta TG concentration was measured in one patient with amegakaryocytic thrombocytopenia, four patients with autoimmune thrombocytopenia (ATP), two patients with thrombotic thrombocytopenia (TTP), and one patient with thrombocytopenia secondary to disseminated intravascular coagulation (DIC). Plasma beta TG was not measurable in amegakaryocytic thrombocytopenia, was normal in ATP, and was increased in TTP and DIC. These data indicate that in thrombocytopenic patients, increased plasma beta TG concentration may result from intravascular platelet consumption with release of platelet constituents in contrast to extravascular platelet destruction by the macrophage-monocyte system.
为阐明β-血小板球蛋白（βTG）在血小板减少症机制鉴别中的作用，我们对1例无巨核细胞性血小板减少症患者、4例自身免疫性血小板减少症（ATP）患者、2例血栓性血小板减少症（TTP）患者和1例弥散性血管内凝血（DIC）继发血小板减少症患者的血浆βTG浓度进行了测定。无巨核细胞性血小板减少症患者血浆βTG无法测得，ATP患者血浆βTG正常，TTP和DIC患者血浆βTG升高。这些数据表明，在血小板减少症患者中，血浆βTG浓度升高可能是由于血管内血小板消耗并释放血小板成分，这与巨噬细胞-单核细胞系统引起的血管外血小板破坏形成对比。
