Rubenstein M D, Wall R T
Am J Hematol. 1981 Jun;10(4):369-73. doi: 10.1002/ajh.2830100406.
Plasma beta-thromboglobulin (beta-TG), a platelet-specific protein, is a marker of intravascular platelet degranulation. We measured plasma beta-thromboglobulin by radioimmunoassay in 13 patients with thrombocytopenia of various etiologies to determine whether or not the test is clinically useful in the differential diagnosis of thrombocytopenia. Four patients with intravascular platelet consumption (three with thrombotic thrombocytopenic purpura and one with vasculitis) had significantly higher plasma beta-thromboglobulin levels than four patients with extravascular platelet destruction due to idiopathic thrombocytopenic purpura. Five patients with thrombocytopenia and decreased numbers of megakaryocytes in the bone marrow also had beta-thromboglobulin levels that were not elevated. Two patients with thrombotic thrombocytopenic purpura achieved clinical remission associated with a decrease in beta-TG level to the normal range. Plasma beta-thromboglobulin determination can be useful in determining the mechanism of thrombocytopenia when bone marrow examination demonstrates adequate megakaryocyte numbers.
血浆β-血小板球蛋白（β-TG）是一种血小板特异性蛋白，是血管内血小板脱颗粒的标志物。我们采用放射免疫分析法对13例不同病因的血小板减少症患者进行血浆β-血小板球蛋白检测，以确定该检测在血小板减少症的鉴别诊断中是否具有临床应用价值。4例血管内血小板消耗患者（3例血栓性血小板减少性紫癜患者和1例血管炎患者）的血浆β-血小板球蛋白水平显著高于4例因特发性血小板减少性紫癜导致血管外血小板破坏的患者。5例血小板减少且骨髓巨核细胞数量减少的患者，其β-血小板球蛋白水平也未升高。2例血栓性血小板减少性紫癜患者临床缓解，同时β-TG水平降至正常范围。当骨髓检查显示巨核细胞数量充足时，血浆β-血小板球蛋白测定有助于确定血小板减少的机制。
