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噬菌体Mu早期启动子上游的整合宿主因子-DNA复合物在功能上是对称的。

The integration host factor-DNA complex upstream of the early promoter of bacteriophage Mu is functionally symmetric.

作者信息

van Ulsen P, Hillebrand M, Zulianello L, van de Putte P, Goosen N

机构信息

Laboratory of Molecular Genetics, Leiden University, The Netherlands.

出版信息

J Bacteriol. 1997 May;179(9):3073-5. doi: 10.1128/jb.179.9.3073-3075.1997.

DOI:10.1128/jb.179.9.3073-3075.1997
PMID:9139933
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC179079/
Abstract

Inversion of the ihf site in the promoter region of the early promoter of bacteriophage Mu did not influence the integration host factor (IHF)-mediated functions. IHF bound to this inverted site could counteract H-NS-mediated repression, directly activate transcription, and support lytic growth of bacteriophage Mu. This implies that the IHF heterodimer and its asymmetrical binding site form a functionally symmetrical complex.

摘要

噬菌体Mu早期启动子区域中整合宿主因子（IHF）位点的倒置并不影响IHF介导的功能。与该倒置位点结合的IHF能够抵消H-NS介导的抑制作用，直接激活转录，并支持噬菌体Mu的裂解生长。这意味着IHF异二聚体及其不对称结合位点形成了功能上对称的复合物。

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本文引用的文献

1
Integration host factor alleviates the H-NS-mediated repression of the early promoter of bacteriophage Mu.整合宿主因子减轻了H-NS介导的对噬菌体Mu早期启动子的抑制作用。
Mol Microbiol. 1996 Aug;21(3):567-78. doi: 10.1111/j.1365-2958.1996.tb02565.x.
2
Function of the C-terminal domain of the alpha subunit of Escherichia coli RNA polymerase in basal expression and integration host factor-mediated activation of the early promoter of bacteriophage Mu.大肠杆菌RNA聚合酶α亚基C末端结构域在噬菌体Mu早期启动子基础表达及整合宿主因子介导的激活中的作用
J Bacteriol. 1997 Jan;179(2):530-7. doi: 10.1128/jb.179.2.530-537.1997.
3
Identification of an UP element within the IHF binding site at the PL1-PL2 tandem promoter of bacteriophage lambda.在噬菌体λ的PL1-PL2串联启动子的整合宿主因子（IHF）结合位点内鉴定一个上游元件（UP元件）。
J Mol Biol. 1996 Jul 26;260(4):484-91. doi: 10.1006/jmbi.1996.0416.
4
Genetic and biochemical analysis of the integration host factor of Escherichia coli.大肠杆菌整合宿主因子的遗传与生化分析
J Mol Biol. 1993 Jun 5;231(3):646-57. doi: 10.1006/jmbi.1993.1316.
5
Characterization of a set of integration host factor mutants deficient for DNA binding.一组缺乏DNA结合能力的整合宿主因子突变体的特性分析。
J Mol Biol. 1993 Nov 5;234(1):45-59. doi: 10.1006/jmbi.1993.1562.
6
The HimA and HimD subunits of integration host factor can specifically bind to DNA as homodimers.整合宿主因子的HimA和HimD亚基可以作为同型二聚体特异性结合DNA。
EMBO J. 1994 Apr 1;13(7):1534-40. doi: 10.1002/j.1460-2075.1994.tb06415.x.
7
Specific photocrosslinking of DNA-protein complexes: identification of contacts between integration host factor and its target DNA.DNA-蛋白质复合物的特异性光交联：整合宿主因子与其靶DNA之间接触位点的鉴定
Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12183-7. doi: 10.1073/pnas.91.25.12183.
8
Symmetry and asymmetry in the function of Escherichia coli integration host factor: implications for target identification by DNA-binding proteins.大肠杆菌整合宿主因子功能中的对称性与不对称性：对DNA结合蛋白识别靶标的启示
Curr Biol. 1994 Jun 1;4(6):477-87. doi: 10.1016/s0960-9822(00)00108-1.
9
The regulation of transcription initiation by integration host factor.
Mol Microbiol. 1995 Apr;16(1):1-7. doi: 10.1111/j.1365-2958.1995.tb02386.x.
10
Participation of the flank regions of the integration host factor protein in the specificity and stability of DNA binding.
J Biol Chem. 1995 Jul 28;270(30):17902-7. doi: 10.1074/jbc.270.30.17902.