噬菌体Mu早期启动子上游的整合宿主因子-DNA复合物在功能上是对称的。
The integration host factor-DNA complex upstream of the early promoter of bacteriophage Mu is functionally symmetric.
作者信息
van Ulsen P, Hillebrand M, Zulianello L, van de Putte P, Goosen N
机构信息
Laboratory of Molecular Genetics, Leiden University, The Netherlands.
出版信息
J Bacteriol. 1997 May;179(9):3073-5. doi: 10.1128/jb.179.9.3073-3075.1997.
Abstract
Inversion of the ihf site in the promoter region of the early promoter of bacteriophage Mu did not influence the integration host factor (IHF)-mediated functions. IHF bound to this inverted site could counteract H-NS-mediated repression, directly activate transcription, and support lytic growth of bacteriophage Mu. This implies that the IHF heterodimer and its asymmetrical binding site form a functionally symmetrical complex.
摘要
噬菌体Mu早期启动子区域中整合宿主因子（IHF）位点的倒置并不影响IHF介导的功能。与该倒置位点结合的IHF能够抵消H-NS介导的抑制作用，直接激活转录，并支持噬菌体Mu的裂解生长。这意味着IHF异二聚体及其不对称结合位点形成了功能上对称的复合物。
相似文献
1
The integration host factor-DNA complex upstream of the early promoter of bacteriophage Mu is functionally symmetric.噬菌体Mu早期启动子上游的整合宿主因子-DNA复合物在功能上是对称的。
J Bacteriol. 1997 May;179(9):3073-5. doi: 10.1128/jb.179.9.3073-3075.1997.
2
Integration host factor alleviates the H-NS-mediated repression of the early promoter of bacteriophage Mu.整合宿主因子减轻了H-NS介导的对噬菌体Mu早期启动子的抑制作用。
Mol Microbiol. 1996 Aug;21(3):567-78. doi: 10.1111/j.1365-2958.1996.tb02565.x.
3
Integration host factor activates the Ner-repressed early promoter of transposable Mu-like phage D108.整合宿主因子激活了转座子类Mu噬菌体D108中被Ner抑制的早期启动子。
J Biol Chem. 1992 Sep 5;267(25):17827-35.
4
Mutual stabilisation of bacteriophage Mu repressor and histone-like proteins in a nucleoprotein structure.噬菌体Mu阻遏物与类组蛋白在核蛋白结构中的相互稳定作用。
J Mol Biol. 1995 Jun 2;249(2):332-41. doi: 10.1006/jmbi.1995.0300.
5
Analysis of the IHF binding site in the regulatory region of bacteriophage Mu.噬菌体Mu调控区中整合宿主因子（IHF）结合位点的分析
Nucleic Acids Res. 1991 Jun 11;19(11):2825-34. doi: 10.1093/nar/19.11.2825.
6
Physical and biological consequences of interactions between integration host factor (IHF) and coliphage lambda late p'R promoter and its mutants.整合宿主因子（IHF）与大肠杆菌噬菌体λ晚期p'R启动子及其突变体之间相互作用的物理和生物学后果。
Gene. 1989 Sep 1;81(1):1-15. doi: 10.1016/0378-1119(89)90331-4.
7
Function of the C-terminal domain of the alpha subunit of Escherichia coli RNA polymerase in basal expression and integration host factor-mediated activation of the early promoter of bacteriophage Mu.大肠杆菌RNA聚合酶α亚基C末端结构域在噬菌体Mu早期启动子基础表达及整合宿主因子介导的激活中的作用
J Bacteriol. 1997 Jan;179(2):530-7. doi: 10.1128/jb.179.2.530-537.1997.
8
Stabilization of bacteriophage Mu repressor-operator complexes by the Escherichia coli integration host factor protein.
Mol Microbiol. 1992 Jun;6(12):1715-22. doi: 10.1111/j.1365-2958.1992.tb00896.x.
9
Action at a distance in Mu DNA transposition: an enhancer-like element is the site of action of supercoiling relief activity by integration host factor (IHF).Mu DNA转座中的远距离作用：一种类似增强子的元件是整合宿主因子（IHF）释放超螺旋活性的作用位点。
EMBO J. 1989 Nov;8(11):3483-9. doi: 10.1002/j.1460-2075.1989.tb08513.x.
10
Regulation of phage Mu repressor transcription by IHF depends on the level of the early transcription.整合宿主因子（IHF）对噬菌体Mu阻遏物转录的调控取决于早期转录的水平。
Nucleic Acids Res. 1989 Dec 25;17(24):10203-12. doi: 10.1093/nar/17.24.10203.
引用本文的文献
1
Integration host factor positively regulates virulence gene expression in Vibrio cholerae.整合宿主因子正向调控霍乱弧菌毒力基因的表达。
J Bacteriol. 2008 Jul;190(13):4736-48. doi: 10.1128/JB.00089-08. Epub 2008 May 2.
本文引用的文献
1
Integration host factor alleviates the H-NS-mediated repression of the early promoter of bacteriophage Mu.整合宿主因子减轻了H-NS介导的对噬菌体Mu早期启动子的抑制作用。
Mol Microbiol. 1996 Aug;21(3):567-78. doi: 10.1111/j.1365-2958.1996.tb02565.x.
2
Function of the C-terminal domain of the alpha subunit of Escherichia coli RNA polymerase in basal expression and integration host factor-mediated activation of the early promoter of bacteriophage Mu.大肠杆菌RNA聚合酶α亚基C末端结构域在噬菌体Mu早期启动子基础表达及整合宿主因子介导的激活中的作用
J Bacteriol. 1997 Jan;179(2):530-7. doi: 10.1128/jb.179.2.530-537.1997.
3
Identification of an UP element within the IHF binding site at the PL1-PL2 tandem promoter of bacteriophage lambda.在噬菌体λ的PL1-PL2串联启动子的整合宿主因子（IHF）结合位点内鉴定一个上游元件（UP元件）。
J Mol Biol. 1996 Jul 26;260(4):484-91. doi: 10.1006/jmbi.1996.0416.
4
Genetic and biochemical analysis of the integration host factor of Escherichia coli.大肠杆菌整合宿主因子的遗传与生化分析
J Mol Biol. 1993 Jun 5;231(3):646-57. doi: 10.1006/jmbi.1993.1316.
5
Characterization of a set of integration host factor mutants deficient for DNA binding.一组缺乏DNA结合能力的整合宿主因子突变体的特性分析。
J Mol Biol. 1993 Nov 5;234(1):45-59. doi: 10.1006/jmbi.1993.1562.
6
The HimA and HimD subunits of integration host factor can specifically bind to DNA as homodimers.整合宿主因子的HimA和HimD亚基可以作为同型二聚体特异性结合DNA。
EMBO J. 1994 Apr 1;13(7):1534-40. doi: 10.1002/j.1460-2075.1994.tb06415.x.
7
Specific photocrosslinking of DNA-protein complexes: identification of contacts between integration host factor and its target DNA.DNA-蛋白质复合物的特异性光交联：整合宿主因子与其靶DNA之间接触位点的鉴定
Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12183-7. doi: 10.1073/pnas.91.25.12183.
8
Symmetry and asymmetry in the function of Escherichia coli integration host factor: implications for target identification by DNA-binding proteins.大肠杆菌整合宿主因子功能中的对称性与不对称性：对DNA结合蛋白识别靶标的启示
Curr Biol. 1994 Jun 1;4(6):477-87. doi: 10.1016/s0960-9822(00)00108-1.
9
The regulation of transcription initiation by integration host factor.
Mol Microbiol. 1995 Apr;16(1):1-7. doi: 10.1111/j.1365-2958.1995.tb02386.x.
10
Participation of the flank regions of the integration host factor protein in the specificity and stability of DNA binding.
J Biol Chem. 1995 Jul 28;270(30):17902-7. doi: 10.1074/jbc.270.30.17902.
Zotero 插件