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2
Integration host factor activates the Ner-repressed early promoter of transposable Mu-like phage D108.整合宿主因子激活了转座子类Mu噬菌体D108中被Ner抑制的早期启动子。
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Transcriptional interference--a crash course.转录干扰——速成课程。
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8
Analysis of the IHF binding site in the regulatory region of bacteriophage Mu.噬菌体Mu调控区中整合宿主因子（IHF）结合位点的分析
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9
Characterization of the lysogenic repressor (c) from transposable Mu-like bacteriophage D108.可转座的类Mu噬菌体D108溶原性阻遏物（c）的特性分析
Nucleic Acids Res. 1991 Nov 11;19(21):5949-56. doi: 10.1093/nar/19.21.5949.

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Spacer mutations in the lac ps promoter.乳糖操纵子启动子中的间隔突变
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Transcription of bacteriophage Mu. I. Hybridization analysis of RNA made in vitro.噬菌体Mu的转录。I. 体外合成RNA的杂交分析。
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3
Primary structure of the himA gene of Escherichia coli: homology with DNA-binding protein HU and association with the phenylalanyl-tRNA synthetase operon.大肠杆菌himA基因的一级结构：与DNA结合蛋白HU的同源性以及与苯丙氨酰-tRNA合成酶操纵子的关联。
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Plasmid vectors for the selection of promoters.用于启动子选择的质粒载体。
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Regulation of the uvrC gene of Escherichia coli K12: localization and characterization of a damage-inducible promoter.大肠杆菌K12的uvrC基因调控：损伤诱导型启动子的定位与特性分析
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A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.一对用于选择双酶切限制片段任一条DNA链的新型M13载体。
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Promoter occlusion: transcription through a promoter may inhibit its activity.启动子阻遏：通过启动子的转录可能会抑制其活性。
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8
Nucleotide sequence of the immunity region of bacteriophage Mu.噬菌体Mu免疫区的核苷酸序列。
Mol Gen Genet. 1982;186(3):315-21. doi: 10.1007/BF00729448.
9
Regulation of Mu transposition. II. The escherichia coli HimD protein positively controls two repressor promoters and the early promoter of bacteriophage Mu.Mu转座的调控。II. 大肠杆菌HimD蛋白正向调控噬菌体Mu的两个阻遏物启动子和早期启动子。
Gene. 1984 Dec;32(3):419-26. doi: 10.1016/0378-1119(84)90017-9.
10
Regulation of Mu transposition. I. Localization of the presumed recognition sites for HimD and Ner functions controlling bacteriophage Mu transcription.Mu转座的调控。I. 控制噬菌体Mu转录的HimD和Ner功能的假定识别位点的定位。
Gene. 1984 Oct;30(1-3):41-6. doi: 10.1016/0378-1119(84)90103-3.

整合宿主因子（IHF）对噬菌体Mu阻遏物转录的调控取决于早期转录的水平。

Regulation of phage Mu repressor transcription by IHF depends on the level of the early transcription.

作者信息

van Rijn P A, Goosen N, Turk S C, van de Putte P

机构信息

Department of Biochemistry, Gorlaeus Laboratoria, Leiden University, The Netherlands.

出版信息

Nucleic Acids Res. 1989 Dec 25;17(24):10203-12. doi: 10.1093/nar/17.24.10203.

DOI:10.1093/nar/17.24.10203
PMID:2532322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC335294/
Abstract

Integration Host Factor (IHF) of E. coli can stimulate both early and repressor transcription of bacteriophage Mu. We introduced several mutations in the early promoter (Pe) and studied the effect of these mutations on the stimulation of early and repressor transcription by IHF. All mutant promoters are still positive regulated by IHF, but the level of stimulation is dependent on the strength of the promoter. The strength of the early promoter has an even greater impact on the regulation of the repressor promoter by IHF: stimulation is observed in the presence of a relatively weak Pe, whereas with a strong Pe the repressor promoter Pc is inhibited by IHF. This inhibition is most probably due to an interference of the early transcription with the opposing repressor transcription. The implication of this type of regulation for the Mu life cycle is discussed.

摘要

大肠杆菌的整合宿主因子（IHF）可刺激噬菌体Mu的早期转录和阻遏物转录。我们在早期启动子（Pe）中引入了几个突变，并研究了这些突变对IHF刺激早期转录和阻遏物转录的影响。所有突变启动子仍受IHF的正调控，但刺激水平取决于启动子的强度。早期启动子的强度对IHF对阻遏物启动子的调控影响更大：在相对较弱的Pe存在时观察到刺激作用，而在强Pe存在时，阻遏物启动子Pc受到IHF的抑制。这种抑制很可能是由于早期转录对相反的阻遏物转录的干扰所致。本文讨论了这种调控类型对Mu生命周期的影响。