Kotz C M, Billington C J, Levine A S
Department of Food Science and Nutrition, University of Minnesota, St. Paul 55108, USA.
Am J Physiol. 1997 Apr;272(4 Pt 2):R1028-32. doi: 10.1152/ajpregu.1997.272.4.R1028.
We evaluated the effect of selective opioid peptides and naltrexone on feeding when injected into the nucleus of the solitary tract (NTS). Doses of 0, 1, 2, 4, and 8 nmol of [D-Ala2,N-Me-Phe4,Gly5-ol]enkephalin (DAMGO, mu-agonist), dynorphin A-(1-17) (DynA-(1-17), kappa-agonist), and [D-Ser2]leucine enkephalin-thr, (delta-agonist) were injected into the NTS in satiated male rats, and food intake was measured at 1, 2, and 4 h. Only DAMGO significantly increased feeding above control levels at doses of 2, 4, and 8 nmol. Doses of 10 and 50 microg naltrexone in the NTS significantly decreased 18-h deprivation-induced feeding. These data suggest that NTS opioid receptors (primarily mu) may be involved in the regulation of feeding.
我们评估了选择性阿片肽和纳曲酮注射到孤束核（NTS）时对进食的影响。在饱足的雄性大鼠的NTS中注射0、1、2、4和8纳摩尔的[D-丙氨酸2，N-甲基苯丙氨酸4，甘氨酸5-醇]脑啡肽（DAMGO，μ-激动剂）、强啡肽A-（1-17）（DynA-（1-17），κ-激动剂）和[D-丝氨酸2]亮氨酸脑啡肽-苏氨酸（δ-激动剂），并在1、2和4小时测量食物摄入量。仅DAMGO在2、4和8纳摩尔剂量时显著增加进食量，使其高于对照水平。在NTS中注射10和50微克纳曲酮剂量显著降低了18小时禁食诱导的进食。这些数据表明，NTS阿片受体（主要是μ受体）可能参与进食调节。
