Chiang E H, Laing T J, Meyer C R, Boes J L, Rubin J M, Adler R S
Department of Radiology, University of Michigan Medical Center, Ann Arbor 48109-0030, USA.
Ultrasound Med Biol. 1997;23(2):205-13. doi: 10.1016/s0301-5629(96)00189-5.
The majority of adults over the age of 65 y develop osteoarthritis (OA), a joint disease characterized by degeneration of articular cartilage and subchondral sclerosis. Early in the disease, the articular cartilage surface begins to change histologically from a smooth to a rough or fibrillated appearance. A prerequisite for any chondroprotective pharmacological intervention is detection of OA in its preclinical phase. Current diagnostic imaging modalities, such as radiographs or (nuclear) magnetic resonance imaging, either cannot directly image the cartilage surface or lack sufficient resolution to detect surface fibrillations. We have developed an ultrasonic technique that can be used to characterize these surface fibrillations directly. We present our in vitro results with validation by laser-based confocal microscopic imaging.
大多数65岁以上的成年人会患骨关节炎（OA），这是一种以关节软骨退变和软骨下硬化为特征的关节疾病。在疾病早期，关节软骨表面在组织学上开始从光滑外观变为粗糙或纤维化外观。任何软骨保护药物干预的前提是在骨关节炎临床前期进行检测。目前的诊断成像方式，如X光片或（核）磁共振成像，要么无法直接对软骨表面成像，要么分辨率不足，无法检测到表面纤维化。我们开发了一种超声技术，可直接用于表征这些表面纤维化。我们展示了我们的体外研究结果，并通过基于激光的共聚焦显微镜成像进行了验证。
