Wong K K, Lo C F, Chen C M
Department of Pharmacology, National Yang Ming University, Taipei, Taiwan, Republic of China.
Planta Med. 1997 Apr;63(2):130-2. doi: 10.1055/s-2006-957628.
The pharmacological action of higenamine in isolated rat aorta was investigated. Although the beta-adrenoceptor antagonist propranolol (1 x 10(-5) M) completely blocked the beta-adrenoceptor agonist higenamine in inducing a positive chronotropic activity in isolated mouse atria, the higenamine-induced aortic relaxation was not completely antagonized by this concentration of propranolol. The present data also demonstrate that the higenamine-induced aortic relaxation was attenuated in the absence of endothelium. These findings suggest that the beta-adrenoceptor specificity to higenamine in aorta is different from that of beta-1 in atria; moreover, the beta-adrenoceptors sensitive to higenamine are mainly located in the endothelial layer.
研究了去甲乌药碱在离体大鼠主动脉中的药理作用。虽然β-肾上腺素受体拮抗剂普萘洛尔（1×10⁻⁵ M）完全阻断了β-肾上腺素受体激动剂去甲乌药碱在离体小鼠心房中诱导的正性变时活性，但该浓度的普萘洛尔并未完全拮抗去甲乌药碱诱导的主动脉舒张。目前的数据还表明，在内皮细胞缺失的情况下，去甲乌药碱诱导的主动脉舒张减弱。这些发现表明，主动脉中去甲乌药碱的β-肾上腺素受体特异性与心房中的β-1不同；此外，对去甲乌药碱敏感的β-肾上腺素受体主要位于内皮细胞层。
