Laboratory of Pharmacology, Faculty of Pharmacy and Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo 202-8585, Japan.
J Pharmacol Sci. 2011;115(2):254-7. doi: 10.1254/jphs.10251sc. Epub 2011 Jan 26.
We compared the effects of the extract from fruits of Nandina domestica Thunberg (NDE) and its constituents, higenamine and nantenine, on contractile responses in isolated guinea-pig trachea. NDE (1 mg/ml) caused biphasic relaxation of the trachea precontracted with high-K(+) stimulation: the fast component was blocked by propranolol and mimicked by higenamine; and the slow was resistant to propranolol and mimicked by nantenine. Ca(2+)-induced contraction under high-K(+) stimulation was antagonized by nantenine or NDE + propranolol. These results suggest that NDE relaxes the trachea quickly through β-adrenoceptor stimulation by higenamine and slowly through Ca(2+) antagonism by nantenine.
我们比较了南天竹果提取物（NDE）及其成分，辛弗林和南天宁，对离体豚鼠气管收缩反应的影响。NDE（1mg/ml）引起高 K+刺激预收缩的气管的双相松弛：快速成分被普萘洛尔阻断并被辛弗林模拟；而缓慢成分对普萘洛尔有抵抗力并被南天宁模拟。高 K+刺激下的 Ca2+诱导收缩被南天宁或 NDE+普萘洛尔拮抗。这些结果表明，NDE 通过辛弗林快速刺激β-肾上腺素能受体松弛气管，通过南天宁缓慢拮抗 Ca2+。
