Hankey G J
Department of Neurology, Royal Perth Hospital, Perth, WA.
Med J Aust. 1997 Apr 21;166(8):419-22.
Randomised controlled trials have shown that thrombolytic therapy for acute ischaemic stroke may reduce the rate of death and disability at three- or six-month follow-up, but may also increase the risk of haemorrhage and early death. Probable predictors of increased risk are severe neurological deficit and early signs of infarction on computed tomography, but these remain to be confirmed. More research is needed to determine which stroke patients will benefit from thrombolysis and the best regimen to use.
随机对照试验表明，急性缺血性中风的溶栓治疗可能会降低3个月或6个月随访时的死亡率和残疾率，但也可能增加出血和早期死亡的风险。风险增加的可能预测因素是严重的神经功能缺损和计算机断层扫描显示的梗死早期迹象，但这些仍有待证实。需要更多的研究来确定哪些中风患者将从溶栓治疗中获益以及最佳的治疗方案。
