Akiyama N, Mitani K, Tanaka Y, Hanazono Y, Motoi N, Zarkovic M, Tange T, Hirai H, Yazaki Y
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo.
Intern Med. 1997 Mar;36(3):221-6. doi: 10.2169/internalmedicine.36.221.
We report a rapidly fatal Bacillus cereus septicemia in a leukemic patient receiving remission-induction therapy. Symptoms resembling food poisoning and fever preceded coma accompanied by neurologic abnormalities. Autopsy revealed necrotizing leptomeningitis with subarachnoid hemorrhage and coagulation necrosis of the liver with bacterial infiltration. These clinicopathologic findings were closely similar to those of reported cases. Because of a rapidly fatal clinical course, suspicion of this syndrome early in the course is important to determine an appropriate treatment. Therefore, we propose that this type of septicemia should be termed as fulminant septicemic syndrome of Bacillus cereus.
我们报告了1例接受缓解诱导治疗的白血病患者发生的迅速致死性蜡样芽孢杆菌败血症。类似食物中毒和发热的症状先于昏迷出现,并伴有神经功能异常。尸检显示坏死性软脑膜炎伴蛛网膜下腔出血,以及肝脏凝固性坏死伴细菌浸润。这些临床病理表现与已报道病例非常相似。由于临床病程迅速致死,在病程早期怀疑此综合征对于确定恰当的治疗很重要。因此,我们建议将这种类型的败血症称为蜡样芽孢杆菌暴发性败血症综合征。