Kraus M F, Maki P M
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
J Neuropsychiatry Clin Neurosci. 1997 Spring;9(2):222-30. doi: 10.1176/jnp.9.2.222.
Symptoms consistent with dysfunction of the frontal lobes can occur following traumatic brain injury (TBI) or other types of acquired brain injury (stroke, aneurysm). These symptoms can include problems with short-term memory, attention, planning, problem solving, impulsivity, disinhibition, poor motivation, and other behavioral and cognitive deficits ("frontal lobe syndrome"). These symptoms may respond to certain drugs, such as dopaminergic agents. This case series describes results of using amantadine in 7 patients with this type of symptom profile (6 with TBI, 1 with meningitis following sinus surgery). Patients received neuropsychiatric examinations and serial neuropsychological testing. All patients showed some degree of positive response. One had side effects that resolved upon discontinuation of drug. The rationale for using dopaminergics is discussed, and pertinent literature is reviewed.
创伤性脑损伤（TBI）或其他类型的获得性脑损伤（中风、动脉瘤）后，可能会出现与额叶功能障碍相符的症状。这些症状可能包括短期记忆、注意力、计划、解决问题、冲动、去抑制、动机缺乏以及其他行为和认知缺陷（“额叶综合征”）。这些症状可能对某些药物有反应，如多巴胺能药物。本病例系列描述了7例具有此类症状特征的患者（6例TBI患者，1例鼻窦手术后发生脑膜炎患者）使用金刚烷胺的结果。患者接受了神经精神检查和系列神经心理学测试。所有患者均表现出一定程度的阳性反应。1例出现副作用，停药后症状缓解。文中讨论了使用多巴胺能药物的理论依据，并对相关文献进行了综述。
