通过其烷基化碱基对信使核糖核酸帽进行特异性蛋白质识别。
Specific protein recognition of an mRNA cap through its alkylated base.
作者信息
Hodel A E, Gershon P D, Shi X, Wang S M, Quiocho F A
出版信息
Nat Struct Biol. 1997 May;4(5):350-4. doi: 10.1038/nsb0597-350.
PMID:9145102
Abstract
The specific binding of N7-methylguanine cap analogues to the RNA methyltransferase VP39 was observed through X-ray crystallography, providing a prototypical structure for a complex between a protein and an mRNA 5' cap.
摘要
通过X射线晶体学观察到N7-甲基鸟嘌呤帽类似物与RNA甲基转移酶VP39的特异性结合，为蛋白质与mRNA 5'帽之间的复合物提供了一个原型结构。
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