Salyer K E, Gendler E, Squier C A
International Craniofacial Institute, Dallas, Texas.
Plast Reconstr Surg. 1997 May;99(6):1721-6.
The successful use of cortical demineralized perforated bone in the treatment of extensive skeletal defects in children is exemplified by this case involving Siamese twins joined at the skull vertex. Four years following extensive skull reconstruction using demineralized perforated bone, an examination revealed successful calvarial reconstruction in one twin. The other twin required additional implants of demineralized perforated bone to fill in defects. However, a histologic examination taken following this additional procedure revealed that these implants neither caused tissue reaction over a 4-year period, nor showed signs of resorption. Bony remodeling and new bone formation were in progress. Compared with other bone substitutes, demineralized perforated bone has proven to be effective in the treatment of large skull defects in children.
颅骨顶部相连的暹罗双胞胎病例体现了去矿化多孔骨在治疗儿童广泛性骨骼缺损中的成功应用。在使用去矿化多孔骨进行广泛颅骨重建四年后，检查发现其中一名双胞胎的颅骨重建成功。另一名双胞胎则需要额外植入去矿化多孔骨以填补缺损。然而，在这一额外手术后进行的组织学检查显示，这些植入物在四年期间既未引起组织反应，也未显示出吸收迹象。骨重塑和新骨形成正在进行。与其他骨替代物相比，去矿化多孔骨已被证明在治疗儿童大型颅骨缺损方面是有效的。
