Valentine J, Rossi E, O'Leary P, Parry T S, Kurinczuk J J, Sly P
Department of Developmental and Rehabilitation Medicine, Princess Margaret Hospital for Children, Perth, Australia.
J Paediatr Child Health. 1997 Apr;33(2):117-20. doi: 10.1111/j.1440-1754.1997.tb01012.x.
To determine the prevalence of thyroid hormone abnormalities and generalized resistance to thyroid hormone in a population of children with attention deficit hyperactivity disorder (ADHD) as compared to reference ranges determined from a control population and hence to determine if routine thyroid hormone screening in children with non-familial ADHD is indicated.
Children attending the State Child Development Centre in Perth, Western Australia with ADHD, as defined by the Diagnostic and Statistical Manual of Mental Disorders (fourth edition) provided the study population. The control population consisted of 353 normal children with a history of allergy in whom radioallergosorbent (RAST) testing was being performed.
The prevalence of thyroid hormone abnormalities in the study population was 2.3% (95% CI 0.6%, 5.7%). There were no cases of generalized resistance to thyroid hormone. The prevalence of thyroid hormone abnormalities in the general population of children and adolescents has been reported to vary between 1 and 3.7%.
Routine thyroid hormone screening is not indicated in children with non-familial ADHD.
与从对照人群确定的参考范围相比，确定注意力缺陷多动障碍（ADHD）儿童人群中甲状腺激素异常和全身性甲状腺激素抵抗的患病率，从而确定非家族性ADHD儿童是否需要进行常规甲状腺激素筛查。
以《精神疾病诊断与统计手册》（第四版）定义的患有ADHD的儿童作为研究对象，这些儿童来自澳大利亚西部珀斯的州立儿童发展中心。对照人群由353名有过敏史且正在进行放射变应原吸附试验（RAST）的正常儿童组成。
研究人群中甲状腺激素异常的患病率为2.3%（95%可信区间0.6%，5.7%）。无全身性甲状腺激素抵抗病例。据报道，儿童和青少年总体人群中甲状腺激素异常的患病率在1%至3.7%之间。
非家族性ADHD儿童无需进行常规甲状腺激素筛查。
