Laboratoire de Génétique Moléculaire et Humaine, Département de Recherche Scientifique, Institut Pasteur, 1 Place Louis Pasteur, 20360, Casablanca, Morocco.
J Community Health. 2011 Dec;36(6):943-8. doi: 10.1007/s10900-011-9393-3.
The aim of this study is to evaluate the degree of familial aggregation of type 2 diabetes mellitus in Morocco and to investigate transmission patterns of the disease and their relationships with patients' clinical profiles. Family history of diabetes and clinical data were collected from 232 unrelated type 2 diabetic Moroccan patients. Diabetes status was recorded for first degree (parents, siblings) and second degree relatives (aunts and uncles from both maternal and paternal sides). Among studied subjects, 50% reported at least one relative with diabetes and 24% had at least one parent with diabetes. Familial aggregation of type 2 diabetes was prominent and more important among first degree relatives than second degree relatives (P < 0.01). Moreover, diabetes was more frequent among mothers than fathers of probands (P = 0.02), but this maternal effect was not observed in second degree relatives. There are no significant differences in clinical and metabolic profiles between patients according to the transmission pattern of the disease. In conclusion, these results suggest familial aggregation and excess maternal transmission of type 2 diabetes in the Moroccan studied population.
本研究旨在评估 2 型糖尿病在摩洛哥的家族聚集程度，并探讨疾病的传递模式及其与患者临床特征的关系。从 232 名无血缘关系的摩洛哥 2 型糖尿病患者中收集了家族糖尿病史和临床数据。记录了一级亲属（父母、兄弟姐妹）和二级亲属（来自父母双方的姑姨叔舅）的糖尿病状况。在所研究的受试者中，50%报告至少有一位亲属患有糖尿病，24%至少有一位父母患有糖尿病。2 型糖尿病的家族聚集在一级亲属中比二级亲属更为明显和重要（P < 0.01）。此外，与先证者的父亲相比，母亲的糖尿病更为常见（P = 0.02），但这种母系效应在二级亲属中并未观察到。根据疾病的传递模式，患者在临床和代谢特征方面没有显著差异。总之，这些结果表明摩洛哥研究人群中存在 2 型糖尿病的家族聚集和母系遗传过度。
