Rawat A K, Mehrotra S, Tripathi S C, Shome U
Pharmacognosy Laboratory, National Botanical Research Institute, Lucknow, India.
J Ethnopharmacol. 1997 Mar;56(1):61-6. doi: 10.1016/s0378-8741(96)01507-3.
The roots of Boerhaavia diffusa L., commonly known as 'Punarnava', are used by a large number of tribes in India for the treatment of various hepatic disorders. In the present study the effect of seasons, thickness of roots and form of dose (either aqueous or powder) were studied for their hepatoprotective action to prove the claims made by the different tribes of India. The hepatoprotective activity of roots of different diameters collected in three seasons, rainy, summer and winter, was examined in thioacetamide intoxicated rats. The results showed that an aqueous extract (2 ml/kg) of roots of diameter 1-3 cm, collected in the month of May (Summer), exhibited marked protection of a majority of serum parameters, i.e. GOT, GPT, ACP and ALP, but not GLDH and bilirubin, thereby suggesting the proper size and time of collection of B. diffusa L. roots for the most desirable results. Further, the studies also proved that the aqueous form of drug (2 ml/kg) administration has more hepatoprotective activity than the powder form; this is probably due to the better absorbtion of the liquid form through the intestinal tract.
胀果甘草，俗称“Punarnava”，其根被印度大量部落用于治疗各种肝脏疾病。在本研究中，研究了季节、根的厚度和给药形式（水剂或粉剂）对其肝脏保护作用的影响，以证实印度不同部落的说法。在硫代乙酰胺中毒的大鼠中检测了在雨季、夏季和冬季三个季节收集的不同直径的根的肝脏保护活性。结果表明，5月（夏季）收集的直径为1 - 3厘米的根的水提取物（2毫升/千克）对大多数血清参数，即谷草转氨酶、谷丙转氨酶、酸性磷酸酶和碱性磷酸酶，表现出显著的保护作用，但对谷氨酸脱氢酶和胆红素没有保护作用，从而表明为获得最理想的结果，胀果甘草根的合适大小和采集时间。此外，研究还证明，药物的水剂形式（2毫升/千克）给药比粉剂形式具有更强的肝脏保护活性；这可能是由于液体形式通过肠道的吸收更好。
