Beck B, Stricker-Krongrad A, Burlet A, Musse N, Nicolas J P, Burlet C
INSERM U.308 Mécanismes de Régulation du Comportement Alimentaire, Nancy, France.
Neurosci Lett. 1997 Apr 11;225(3):153-6. doi: 10.1016/s0304-3940(97)00226-7.
In this study, we measured hypothalamic neuropeptide Y (NPY) and the food preference in weanling and adult monosodium glutamate (MSG)-lesioned and control rats. The MSG lesion was induced by three subcutaneous injections (4 g/kg body wt) during the first week of life of the rats. All treated and control weanling rats strongly preferred a high carbohydrate (HC) diet to a high fat (HF) diet. Adult control rats ate 60% more HF diet (P < 0.001) and 25% less HC diet (P < 0.01) than MSG-treated rats. At weaning and in adulthood, NPY concentrations in MSG-rats were markedly lower in the arcuate and paraventricular nuclei (P < 0.01 or less) than in control rats. The MSG treatment did not affect carbohydrate preference observed at weaning. It was associated with a limited development of fat appetite in adulthood. NPY could influence the dietary preferences more in adulthood, likely when all neuropeptidergic systems are mature.
在本研究中，我们测量了断奶期和成年期的谷氨酸单钠（MSG）损伤大鼠及对照大鼠的下丘脑神经肽Y（NPY）和食物偏好。MSG损伤是在大鼠出生后第一周通过三次皮下注射（4 g/kg体重）诱导产生的。所有接受处理的断奶大鼠和对照断奶大鼠都强烈偏好高碳水化合物（HC）饮食而非高脂肪（HF）饮食。成年对照大鼠比接受MSG处理的大鼠多吃60%的HF饮食（P < 0.001），少吃25%的HC饮食（P < 0.01）。在断奶期和成年期，MSG处理大鼠的弓状核和室旁核中的NPY浓度明显低于对照大鼠（P < 0.01或更低）。MSG处理不影响断奶时观察到的对碳水化合物的偏好。它与成年期脂肪食欲的有限发展有关。NPY可能在成年期对饮食偏好的影响更大，可能是在所有神经肽能系统都成熟的时候。
