Van der Does A J, Dingemans P M, Linszen D H, Nugter M A, Scholte W F
Department of Psychiatry, Leiden University, Leiden, The Netherlands.
Schizophr Res. 1996 Mar;19(1):61-71. doi: 10.1016/0920-9964(95)00046-1.
The relationships among symptoms, cognitive functioning and social functioning were investigated in patients with schizophrenia over a period of 15 months. Patients with a mood disorder, a normal control group and a sample of parents of the schizophrenic patients also completed the cognitive tests. In the schizophrenia sample, only disorganisation was correlated with cognitive performance, which was interpreted as further evidence that disorganisation is a separate symptom dimension of schizophrenia. Against expectations, with two of three measurements no significant correlations were found between negative symptoms and cognitive performance. With these two measurements, however, a curvilinear association between negative symptoms and cognitive performance was observed, suggesting that negative symptoms are not a unitary concept. Finally, tentative evidence could be obtained for speed of information processing and selective attention as markers for vulnerability, although the latter is not specific for schizophrenia.
在15个月的时间里，对精神分裂症患者的症状、认知功能和社会功能之间的关系进行了调查。患有情绪障碍的患者、正常对照组以及精神分裂症患者的父母样本也完成了认知测试。在精神分裂症样本中，只有紊乱与认知表现相关，这被解释为进一步证明紊乱是精神分裂症一个独立症状维度的证据。与预期相反，在三次测量中的两次中，未发现阴性症状与认知表现之间存在显著相关性。然而，在这两次测量中，观察到阴性症状与认知表现之间存在曲线关联，这表明阴性症状不是一个单一的概念。最后，尽管选择性注意并非精神分裂症所特有，但可以获得初步证据表明信息处理速度和选择性注意可作为易感性的标志物。
