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通过第二个肌球蛋白头部的附着,收缩肌肉中的动力冲程得以快速再生。

Rapid regeneration of power stroke in contracting muscle by attachment of second myosin head.

作者信息

Huxley A F, Tideswell S

机构信息

Physiological Laboratory, University of Cambridge, UK.

出版信息

J Muscle Res Cell Motil. 1997 Feb;18(1):111-4. doi: 10.1023/a:1018641218961.

DOI:10.1023/a:1018641218961
PMID:9147987
Abstract

When Lombardi and colleagues reported the phenomenon of rapid regeneration of the power stroke after a quick release of muscle fibre during a tetanus, they gave an explanation in terms of detachment of cross-bridges and re-attachment further along the thin filament. We show here that the phenomenon can also be explained on assumptions that lead to a majority of myosin molecules being attached by only one head during steady isometric contraction; the other head may then become attached after a quick release and can add its contribution to the early tension recovery after a second release.

摘要

当隆巴迪及其同事报告了在强直收缩期间快速释放肌肉纤维后动力冲程快速再生的现象时,他们根据横桥的脱离以及沿细肌丝进一步重新附着给出了解释。我们在此表明,该现象也可以基于以下假设来解释:在稳定的等长收缩期间,大多数肌球蛋白分子仅由一个头部附着;另一个头部可能在快速释放后附着,并可以为第二次释放后的早期张力恢复做出贡献。

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