Dryll A, Cazalis P, Ryckewaert A
J Clin Pathol. 1977 Sep;30(9):822-6. doi: 10.1136/jcp.30.9.822.
Two types of lymphocyte tubular structures were studied by electron microscopy in 80 patients with classic or definite rheumatoid arthritis (RA). Fifteen patients with unequivocal systemic lupus erythematosus (SLE) and 10 healthy persons were studied as controls. Lymphocyte tubulo-reticular structures were found in 13 of the 80 patients with RA and in 10 of the 15 patients with SLE. No tubuloreticular structures were found in any of the healthy subjects. In the RA patients antinuclear antibodies, LE cell phenomenon, and chlorambucil treatment were associated significantly with these inclusions but disease activity was not related to their presence. In cases in which tubuloreticular structures were present the number of cells containing inclusions was on average much lower in patients with RA than in those with SLE. Lymphocyte tubular parallel arrays were found in all the patients with RA and SLE and in all the healthy persons. In all three groups the average number of cells containing parallel tubular arrays was similar.
通过电子显微镜对80例典型或确诊类风湿关节炎（RA）患者的两种淋巴细胞管状结构进行了研究。15例明确的系统性红斑狼疮（SLE）患者和10名健康人作为对照进行研究。在80例RA患者中有13例以及15例SLE患者中有10例发现了淋巴细胞管-网状结构。在任何健康受试者中均未发现管-网状结构。在RA患者中，抗核抗体、LE细胞现象和苯丁酸氮芥治疗与这些包涵体显著相关，但疾病活动度与它们的存在无关。在存在管-网状结构的病例中，RA患者中含有包涵体的细胞数量平均比SLE患者少得多。在所有RA和SLE患者以及所有健康人中均发现了淋巴细胞管状平行排列。在所有三组中，含有平行管状排列的细胞平均数量相似。
