Böttinger E P, Letterio J J, Roberts A B
Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland, USA.
Kidney Int. 1997 May;51(5):1355-60. doi: 10.1038/ki.1997.185.
This paper reviews the basic biology and biochemistry of the TGF-beta isoforms including their unique serine-threonine receptors and signaling intermediates. Dysregulation of TGF-beta expression and/or receptor/signaling function have been implicated in a wide variety of pathologies. We will discuss mechanisms underlying some of these disease processes as gained from study of transgenic mice in which expression of TGF-beta 1 has either been lost by targeted deletion of its gene, is overexpressed in a tissue-specific manner, or blocked by its latency associated peptide.
本文综述了转化生长因子-β（TGF-β）亚型的基本生物学和生物化学特性，包括其独特的丝氨酸-苏氨酸受体和信号转导中间体。TGF-β表达和/或受体/信号功能的失调与多种病理状况有关。我们将讨论从转基因小鼠研究中获得的一些疾病过程的潜在机制，在这些转基因小鼠中，TGF-β1的表达要么通过其基因的靶向缺失而丧失，要么以组织特异性方式过表达，要么被其潜伏相关肽阻断。
