来自转化生长因子-β转基因小鼠的经验教训。
Lessons from TGF-beta transgenic mice.
作者信息
Böttinger E P, Kopp J B
机构信息
Division of Nephrology, Albert Einstein College of Medicine, Bronx, NY 10461-1602, USA.
出版信息
Miner Electrolyte Metab. 1998;24(2-3):154-60. doi: 10.1159/000057364.
Aberrant expression of TGF-beta and/or receptor/signaling function is present in a wide variety of disease processes. Overexpression of TGF-beta isoforms in transgenic mice using tissue-specific promoters has provided model systems to study the effects of increased activity of TGF-beta in the intact organism. We will review the pertinent features of some of these models, and discuss new insights provided by these studies into regulation and role of TGF-beta in health and disease.
转化生长因子-β（TGF-β）和/或受体/信号功能的异常表达存在于多种疾病过程中。利用组织特异性启动子在转基因小鼠中过表达TGF-β亚型，为研究TGF-β活性增加在完整生物体中的作用提供了模型系统。我们将回顾其中一些模型的相关特征，并讨论这些研究对TGF-β在健康和疾病中的调节及作用所提供的新见解。
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