3-氨基吡啶对皮层神经元的惊厥作用。

Convulsive effects of 3-aminopyridine on cortical neurones.

作者信息

Baranyi A, Fehér O

出版信息

Electroencephalogr Clin Neurophysiol. 1979 Dec;47(6):745-51. doi: 10.1016/0013-4694(79)90303-1.

Abstract

The authors examined the effects of 3-aminopyridine (3-AP) on pyramidal tract neurones in the motor cortex of anesthetised cats. 3-AP proved to be a strong convulsive agent. Local application of 3-AP in concentrations of 15-20 mM resulted in typical paroxysmal alterations of neuronal activity: (a) enhancement of background firing, (b) augmentation of EPSPs, (c) depression of IPSPs and (d) single and serial paroxysmal depolarization shifts (PDSs). Serial PDSs were reflected by large synchronous waves in the surface ECoG.

摘要

作者研究了3-氨基吡啶（3-AP）对麻醉猫运动皮层锥体束神经元的影响。结果证明3-AP是一种强效惊厥剂。局部应用浓度为15-20 mM的3-AP会导致神经元活动出现典型的阵发性改变：（a）背景放电增强，（b）兴奋性突触后电位（EPSP）增大，（c）抑制性突触后电位（IPSP）抑制，以及（d）单个和连续的阵发性去极化偏移（PDS）。连续的PDS在头皮脑电图（ECoG）中表现为大的同步波。