Wright M M, McGehee R F, Pederson J E
Department of Ophthalmology, University of Minnesota, Minneapolis 55455, USA.
Ophthalmic Surg Lasers. 1997 May;28(5):370-6.
The authors studied the efficacy and complications of intraoperative mitomycin-C in glaucoma associated with ocular inflammation.
The authors retrospectively reviewed the medical records of 24 consecutive patients (24 eyes) with glaucoma and ocular inflammation who had been treated with trabeculectomy and intraoperative mitomycin-C. Patient ages ranged from 10 to 83 years (mean 43 years). All patients were observed for at least 6 months.
With a mean follow-up time of 14.6 months, 18 of the 24 patients (75%) retained vision and had an intraocular pressure of 21 mm Hg or lower with or without medications (range 4 to 21 mm Hg; mean 13.4 mm Hg). Fifteen of 24 patients (62%) had an intraocular pressure of 21 mm Hg or lower with no medications. Three patients required tube shunt implants. One patient had a retinal detachment and lost light perception. One patient had endophthalmitis 14 months after surgery. Seven of 24 patients lost two or more lines of Snellen acuity.
Trabeculectomy with mitomycin-C can control intraocular pressure in glaucoma associated with ocular inflammation, but complications are frequent.
作者研究了术中使用丝裂霉素C治疗与眼部炎症相关青光眼的疗效及并发症。
作者回顾性分析了24例（24只眼）接受小梁切除术并术中使用丝裂霉素C治疗的青光眼合并眼部炎症患者的病历。患者年龄在10至83岁之间（平均43岁）。所有患者均观察至少6个月。
平均随访时间为14.6个月，24例患者中有18例（75%）视力得以保留，眼压在使用或未使用药物的情况下均维持在21 mmHg或更低（范围4至21 mmHg；平均13.4 mmHg）。24例患者中有15例（62%）在未使用药物的情况下眼压维持在21 mmHg或更低。3例患者需要植入引流管。1例患者发生视网膜脱离并丧失光感。1例患者在术后14个月发生眼内炎。24例患者中有7例视力下降两行或更多。
小梁切除术联合丝裂霉素C可控制与眼部炎症相关青光眼的眼压，但并发症较为常见。
