风湿性疾病中血清可溶性CD44异构体v5水平升高仅限于血清阳性类风湿性关节炎。
Increased serum levels of soluble CD44-isoform v5 in rheumatic diseases are restricted to seropositive rheumatoid arthritis.
作者信息
Haberhauer G, Kittl E M, Skoumal M, Hübl W, Wagner E, Bayer P M, Bauer K, Dunky A
机构信息
5th Department of Internal Medicine and Rheumatology, Wilhelminen-Hospital, Vienna, Austria.
出版信息
Acta Med Austriaca. 1997;24(1):23-5.
Serum levels of sCD44v5 were measured in 134 patients with definite inflammatory rheumatic diseases (IRD) using a sandwich type ELISA. 94 patients suffered from erosive IgM-rheumatoid factor positive rheumatoid arthritis (RA+), 20 with undifferentiated seronegative polyarthritis, 12 with osteoarthropathia psoriatica and psoriasis vulgaris, 3 with systemic lupus erythematosus, 3 with scleroderma and 2 with reactive arthritis. Elevated serum levels (> 58 ng/ml to 221 ng/ml; median: 93 ng/ml) were only detected in 54/94 (57%) patients with RA+, but not in other IRD. They correlated with advanced stages of disease (Steinbrocker stages III + IV; p < 0.05), elevated CRP-levels (p < 0.01) and higher measurements of IgM rheumatoid factor.
采用夹心型酶联免疫吸附测定法（ELISA）对134例确诊的炎症性风湿性疾病（IRD）患者的血清sCD44v5水平进行了检测。其中94例为侵蚀性IgM类风湿因子阳性类风湿关节炎（RA+）患者，20例为未分化血清阴性多关节炎患者，12例为银屑病性骨关节病和寻常型银屑病患者，3例为系统性红斑狼疮患者，3例为硬皮病患者，2例为反应性关节炎患者。仅在54/94（57%）的RA+患者中检测到血清水平升高（>58 ng/ml至221 ng/ml；中位数：93 ng/ml），而在其他IRD患者中未检测到。它们与疾病的晚期阶段（Steinbrocker III + IV期；p < 0.05）、升高的C反应蛋白水平（p < 0.01）以及更高的IgM类风湿因子测量值相关。
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