Schouten L J, Hupperets P S, Jager J J, Volovics L, Wils J A, Verbeek A L, Blijham G H
Department of Cancer Registration, Comprehensive Cancer Centre IKL, Maastricht, The Netherlands.
Breast Cancer Res Treat. 1997 May;43(3):217-23. doi: 10.1023/a:1005790531122.
Several risk factors for the etiology of breast cancer have also been correlated with the prognosis of breast cancer. However, the published studies have yielded conflicting results. Women under 71 years of age with stage I, II, or III breast cancer were eligible for inclusion in a clinical study. 866 patients with breast cancer entered the study, of whom 463 had positive lymph nodes. Survival was analysed using Cox's proportional hazards model. Age at menarche parity, age at menopause and family history were not consistently related to survival. Young age at first full-term pregnancy was related to decreased survival (adjusted relative risk (RR): 1.69, 95% confidence intervals (95% CI): 1.04-2.68), but it cannot be excluded that this result was due to chance alone. Use of oral contraceptives was not correlated with survival (RR: 1.10, 95% CI: 0.80-1.51) nor was family history (RR: 0.93, 95% CI: 0.66-1.30). This study provided little support for the hypothesis that risk factors for breast cancer are related to survival.
乳腺癌病因的几个风险因素也与乳腺癌的预后相关。然而，已发表的研究结果相互矛盾。年龄在71岁以下、患有I期、II期或III期乳腺癌的女性符合纳入一项临床研究的条件。866例乳腺癌患者进入该研究，其中463例有淋巴结阳性。使用Cox比例风险模型分析生存率。初潮年龄、产次、绝经年龄和家族史与生存率并无一致的关联。首次足月妊娠时年龄较小与生存率降低相关（调整后相对风险（RR）：1.69，95%置信区间（95%CI）：1.04 - 2.68），但不能排除该结果仅是偶然所致。口服避孕药的使用与生存率无关（RR：1.10，95%CI：0.80 - 1.51），家族史也与生存率无关（RR：0.93，95%CI：0.66 - 1.30）。这项研究几乎没有支持乳腺癌风险因素与生存率相关这一假设。
