Zhao M, Laissue J A, Zimmermann A
Institute of Pathology of the University, Berne, Switzerland.
Histol Histopathol. 1997 Apr;12(2):367-74.
In this retrospective study, we systematically analyzed hepatocyte apoptosis in three situations of hepatic iron overload (hereditary hemochromatosis; hepatic iron overload of unknown reason; iron overload due to hyperhemolysis or exogenous iron administration). Apoptosis was assessed by use of DNA nick end-labelling. The results suggest that hepatic iron overload is associated with an increased apoptotic rate of hepatocytes, and that iron-laden hepatocytes in hemochromatosis behave, with respect to apoptosis, differently from those in other states of iron overload. The hepatocyte apoptotic rate tended to increase as a function of the degree of iron storage. As in other pathological liver changes studied so far, an elevated apoptotic rate of hepatocytes predominated in the pericentral parts of liver acini in hemochromatosis, but not in the two other groups of hepatic iron overload. Possible mechanisms for this difference are discussed, particularly with respect to a participation of the Kupffer cell system.
在这项回顾性研究中，我们系统地分析了肝铁过载的三种情况下（遗传性血色素沉着症；不明原因的肝铁过载；高溶血或外源性铁剂给药导致的铁过载）肝细胞的凋亡情况。通过DNA缺口末端标记法评估凋亡。结果表明，肝铁过载与肝细胞凋亡率增加有关，并且血色素沉着症中含铁的肝细胞在凋亡方面的表现与其他铁过载状态下的肝细胞不同。肝细胞凋亡率倾向于随着铁储存程度的增加而升高。与迄今为止研究的其他病理性肝脏变化一样，血色素沉着症中肝腺泡中央周围部分肝细胞凋亡率升高占主导，但在其他两组肝铁过载中并非如此。讨论了造成这种差异的可能机制，特别是关于库普弗细胞系统的参与情况。
